Peutz–Jeghers syndrome also known as hereditary intestinal polyposis syndrome is an autosomal dominant genetic disease characterized by the development of benign hamartomatous polyps in the gastrointestinal tract and hyperpigmented macules on the lips and oral mucosa (melanosis). Peutz–Jeghers syndrome has an incidence of approximately 1 in 25000 to 300000 births.
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