Tags: Anatomical Structure, Brain.
Periaqueductal gray (PAG; also called the central gray) is the gray matter located around the cerebral aqueduct within the tegmentum of the midbrain. It plays a role in the descending modulation of pain and in defensive behaviour. The ascending pain and temperature fibers of the spinothalamic tract also send information to the PAG via the spinomesencephalic tract (so-named because the fibers originate in the spine and terminate in the PAG in the mesencephalon or midbrain).
