Pentagastrin (trade name Peptavlon) is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid pepsin and intrinsic factor and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.Pentagastrin binds to the cholecystokinin-B receptor which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system.
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