Tags: Disease.
Pearson syndrome is a mitochondrial disease characterized by sideroblastic anemia and exocrine pancreas dysfunction. Other clinical features are failure to thrive pancreatic fibrosis with insulin-dependent diabetes and exocrine pancreatic deficiency muscle and neurologic impairment and frequently early death. It is usually fatal in infancy. The few patients who survive into adulthood often develop symptoms of Kearns-Sayre syndrome. It is caused by a deletion in mitochondrial DNA.