Tags: Protein.
Paraplegin is a protein that in humans is encoded by the SPG7 gene.This gene encodes a nuclear-encoded mitochondrial metalloprotease protein that is a member of the AAA protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking intracellular motility organelle biogenesis protein folding and proteolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.