P38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases that are responsive to stress stimuli such as cytokines ultraviolet irradiation heat shock and osmotic shock and are involved in cell differentiation apoptosis and autophagy.p38 MAP Kinase (MAPK) also called RK or CSBP (Cytokinin Specific Binding Protein) is the mammalian orthologue of the yeast Hog1p MAP kinase which participates in a signaling cascade controlling cellular responses to cytokines and stress.Four p38 MAP kinases p38-α (MAPK14) -β (MAPK11) -γ (MAPK12 / ERK6) and -δ (MAPK13 / SAPK4) have been identified.