Oxamniquine is an anthelmintic with schistosomicidal activity against Schistosoma mansoni but not against other Schistosoma spp. Oxamniquine is a potent single-dose agent for treatment of S. mansoni infection in man and it causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery but can no longer release eggs.
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