Tags: Chemical Compound, Chemical Substance.
O6-Benzylguanine (O6-BG) is a synthetic derivative of guanine. It is an antineoplastic agent. It exerts its effect by acting as an inhibitor of the enzyme O6-alkylguanine-DNA alkyltransferase which leads to interruption of DNA repair and increases the potency of other chemotherapeutic agents that damage DNA such as temozolomide.O6-BG is also used as a biochemical tool in the study of DNA repair mechanisms.
