Tags: Drug.
O-1812 is an eicosanoid derivative related to anandamide that acts as a potent and highly selective agonist for the cannabinoid receptor CB1 with a Ki of 3.4nM at CB1 and 3870nM at CB2. Unlike most related compounds O-1812 is metabolically stable against rapid breakdown by enzymes and produces a cannabinoid-like discriminative effect in rats which is similar but not identical to that produced by cannabinoid drugs of other chemical classes.
