Tags: Protein.
Niemann-Pick C1-Like 1 (NPC1L1) is a gene associated with NPC1 which mutation results in Niemann-Pick disease. It codes for Niemann-Pick C1-like protein 1 found on the gastrointestinal tract epithelial cells as well as in hepatocytes. Specifically it appears to bind to a critical mediator of cholesterol absorption.The drug ezetimibe blocks the NPC1L1 causing a reduction in cholesterol absorption resulting in a blood cholesterol reduction of between 15-20%.