Tags: Protein.
Enhancer of filamentation 1 is a protein that in humans is encoded by the NEDD9 gene.Synonyms are CASL HEF1 p105CAS.It is a member of the CAS (Crk-associated substrates) family.It is organized into domains from N to C terminus: SH3 domain SH2-binding substrate domain (which when phosphorylated binds SH2 domains) serine-rich domain SBD (putative Src-binding domain) and a C-terminal domain that binds GEF (GDP-exchange factor) proteins of the NSP (Novel SH2 domain containing Protein) family such as BCAR3.