Tags: Drug.
(+)-Naloxone (dextro-naloxone) is a drug which is the unnatural enantiomer of the opioid antagonist drug (-)-naloxone. Unlike normal naloxone (+)-naloxone has no significant affinity for opioid receptors but instead has been discovered to act as a selective antagonist of Toll-like receptor 4. This receptor is involved in immune system responses and activation of TLR4 induces glial activation and release of inflammatory mediators such as TNF-α and Interleukin-1.
