Nalorphine (INN; Lethidrone Nalline) also known as N-allyl-normorphine is a mixed opioid agonist-antagonist. It acts at two opioid receptors at the mu receptor it has antagonistic effects and at the kappa receptors it exerts agonistic characteristics. It is used to reverse opioid overdose and (starting in the 1950s) in a challenge test to determine opioid dependence.
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