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Several varieties of mumps vaccine have been used since 1949 and at least 10 strains were in use in 2006:The first vaccine was a killed mumps virus vaccine developed in 1948 and used in the United States from 1950-1978. This vaccine produced little immune memory thus had a short duration of effect. In the U.S.A. it was supplanted by Mumpsvax and then MMR.All subsequent preparations have been live virus attenuated by multiple passages through animal cells of one or more species.

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