Tags: Protein.
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase mitochondrial is an enzyme that in humans is encoded by the MTHFD2 gene.This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD.