Tags: Ethnic Group.
The Mosopelea or Ofo were a Native American Siouan-speaking tribe who historically inhabited the upper Ohio River. In reaction to Iroquois Confederacy invasions to take control of hunting grounds in the 1600s they moved south to the lower Mississippi River. They finally settled in central Louisiana where they assimilated with the Siouan-speaking Biloxi and the Tunica people. They are generally classified with the speakers of the Siouan Ofo language.