Tags: Chemical Compound, Chemical Substance.

Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates the name mafodotin refers to MMAF plus its attachment structure to the antibody.

Monomethylauristatin_F.svg
IUPAC name
(S)-2-((2R3R)-3-((S)-1-((3R4S5S)-4-((S)-N3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid

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