Tags: Chemical Compound, Chemical Substance.

Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity it cannot be used as a drug itself; instead it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates the name vedotin refers to MMAE plus its linking structure to the antibody.

Monomethylauristatin_E.svg
IUPAC name
(S)-N-((3R4S5S)-1-((S)-2-((1R2R)-3-(((1S2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

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