Tags: Disease.

MODY 4 is a form of maturity onset diabetes of the young.MODY 4 arises from mutations of the Pdx-1 homeobox gene on chromosome 13. Pdx-1 is a transcription factor vital to the development of the embryonic pancreas. Even in adults it continues to play a role in the regulation and expression of genes for insulin GLUT2 glucokinase and somatostatin. MODY 4 is so rare that only a single family has been well-studied.

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