Tags: Protein.
Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a protein that in humans is encoded by the MDK gene.Midkine is a basic heparin-binding growth factor of low molecular weight and forms a family with pleiotrophin (NEGF1 46% homologous with MK). It is a nonglycosylated protein composed of two domains held by disulfide bridges. It is a developmentally important retinoic acid-responsive gene product strongly induced during mid-gestation hence the name midkine .