Tags: Chemical Compound, Chemical Substance.
Methylmalonic acid (MMA) is a dicarboxylic acid that is a C-methylated derivative of malonate. The coenzyme A linked form of methylmalonic acid methylmalonyl-CoA is converted into succinyl-CoA by methylmalonyl-CoA mutase in a reaction that requires vitamin B12 as a cofactor. In this way it enters the Krebs cycle and is thus part of one of the anaplerotic reactions.
