Tags: Enzyme.
In enzymology a methylmalonate-semialdehyde dehydrogenase (acylating) (EC 1.2.1.27) is an enzyme that catalyzes the chemical reaction2-methyl-3-oxopropanoate + CoA + H2O + NAD+ propanoyl-CoA + HCO3- + NADHThe 4 substrates of this enzyme are 2-methyl-3-oxopropanoate CoA H2O and NAD+ whereas its 3 products are propanoyl-CoA HCO3- and NADH.This enzyme belongs to the family of oxidoreductases specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor.