Methotrexate (INN AAN BAN and USAN) /mɛθɵˈtrɛkseɪt/ abbreviated MTX and formerly known as amethopterin is an antimetabolite and antifolate drug. It is used in treatment of cancer autoimmune diseases ectopic pregnancy and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate began to replace the more toxic antifolate aminopterin starting in the 1950s.
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