Tags: Chemical Compound, Chemical Substance.

Mesembrenone is an alkaloid constituent of Sceletium tortuosum (Kanna). Similar to modern synthetic antidepressants it is a potent (IC50 < 1 μM) selective inhibitor of the serotonin transporter (SERT) (that is a selective serotonin reuptake inhibitor; Ki = 27 nM) and also a phosphodiesterase 4 (PDE4) inhibitor (Ki = 470 nM).

Mesembrenone2DACS.svg
IUPAC name
(3aR7aS)-3a-(34-Dimethoxyphenyl)-1-methyl-1233a77a-hexahydro-6H-indol-6-one

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