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Mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes – abbreviated to MELAS – is one of the family of mitochondrial cytopathies which also include MERRF and Leber’s hereditary optic neuropathy. It was first characterized under this name in 1984. A feature of these diseases is that they are caused by defects in the mitochondrial genome which is inherited purely from the female parent.

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