Mecillinam (INN) or amdinocillin (USAN) trade name Coactin is an extended-spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2 (PBP2) and is only considered to be active against Gram-negative bacteria. It is used primarily in the treatment of urinary tract infections and has also been used to treat typhoid and paratyphoid fever. Because mecillinam has very low oral bioavailability an orally active prodrug was developed: pivmecillinam.
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