Tags: Disease.
MASA syndrome also called CRASH syndrome and Gareis-Mason syndrome is a rare X-linked recessive neurological disorder. The acronym MASA describes the four major symptoms – Mental retardation Aphasia Shuffling gait and Adducted thumbs. A more suitable name for this syndrome is L1 syndrome. The disorder has been associated with mutations in the L1CAM gene. This syndrome has severe symptoms in males while females are carriers because only one X-chromosome is affected.