Tags: Enzyme.
Malate dehydrogenase (NAD(P)+) (EC 1.1.1.299 MdH II NAD(P)+-dependent malate dehyrogenase) is an enzyme with system name (S)-malate:NAD(P)+ oxidoreductase. This enzyme catalyses the following chemical reaction (S)-malate + NAD(P)+ oxaloacetate + NAD(P)H + H+This enzyme which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum catalyses only the reduction of oxaloacetate and can use NAD+ and NADP+ with similar specific activity.