Tags: Chemical Compound, Chemical Substance.
LY294002 is a morpholine-containing chemical compound that is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Two of these are the proto-oncogene serine/threonine-protein kinase (PIM1) and the phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit gamma isoform. With an IC50 of 1.4 µM it is somewhat less potent than wortmannin another well-known PI3 kinase inhibitor. However LY294002 is a reversible inhibitor of PI3K whereas wortmannin acts irreversibly.
