Tags: Drug.
LR132 or (+)-34-dichloro-N-[(1R2S)-2-(1-pyrrolidinyl)cyclohexyl]benzeneethanamine is a selective sigma receptor antagonist with a reported binding affinity of Ki = 2 ± 0.1 nM for the sigma-1 receptor and more than 350 times selectivity over the sigma-2 receptor.Consistent with other reported sigma receptor antagonists pretreating Swiss Webster mice with LR132 significantly decreases the convulsivity and lethality of cocaine.
