Tags: Disease.
Leukoencephalopathy with vanishing white matter (VWM disease) is an autosomal recessive neurological disease. The cause of the disease are mutations in any of the 5 genes encoding subunits of the translation initiation factor EIF-2B: EIF2B1 EIF2B2 EIF2B3 EIF2B4 or EIF2B5. The disease belongs to a family of conditions called the Leukodystrophies.