Lesch–Nyhan syndrome (LNS) also known as Nyhan’s syndrome Kelley-Seegmiller syndrome and juvenile gout is a rare inherited disorder caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT) produced by mutations in the HPRT gene located on the X chromosome. LNS affects about one in 380000 live births.
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