Tags: Disease.
A lentigo (plural: lentigines) is a small pigmented spot on the skin with a clearly defined edge surrounded by normal-appearing skin. It is a harmless (benign) hyperplasia of melanocytes which is linear in its spread. This means the hyperplasia of melanocytes is restricted to the cell layer directly above the basement membrane of the epidermis where melanocytes normally reside. This is in contrast to the nests of multi-layer melanocytes found in moles (melanocytic nevi).
