Tags: Protein.
Laforin encoded by the EPM2A gene is a glucan phosphate and an adaptor protein which is mutated in patients with Lafora disease. It contains a dual specificity phosphatase domain (DSP) and a carbohydrate binding module subtype 20 [1] (CBM20). Its physiological substrate has yet to be identified and the molecular mechanisms in which mutated laforin causes Lafora disease is unknown though there has been progress made in the study by Ortolano et al.