Tags: Drug.
L-733060 is a drug developed by Merck Sharpe & Dohme which acts as an orally active non-peptide selective antagonist for the NK1 receptor binding with a Ki of 0.08nM. Only one enantiomer is active which has made it the subject of several asymmetric synthesis efforts.L-733060 has antidepressant and anxiolytic effects in animal studies and reduces both the dopamine release and neurotoxicity produced by methamphetamine and cocaine.
