Tags: Chemical Compound, Chemical Substance.
L-694247 is a somewhat selective 5-HT1D agonist with a 10-fold greater affinity for the 5-HT1B receptor and 25-fold greater affinity for the 5-HT1A receptor. When L-694247 was injected intraventricularly in dehydrated rats it inhibited water intake. Pre-treatment with a 5-HT1D antagonist abolished this effect. Administration of L-694247 to normally hydrated rats had no effect on water intake.
