Ku is a protein that binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. Ku is evolutionarily conserved from bacteria to human. The ancestral bacterial Ku is a homodimer (two copies of the same protein bound to each other). Eukaryotic Ku is a heterodimer of two polypeptides Ku70 (XRCC6) and Ku80 (XRCC5) so named because the molecular weight of the human Ku proteins is around 70 kDa and 80 kDa.
thumbnail
arm
q
band
11, 35
chromosome
2, 22
EntrezGene
2547, 7520
HGNCid
4055, 12833
locus supplementary data
-q13
OMIM id
152690, 194364
PDB
1JEY
RefSeq
NM_001469, NM_021141
symbol
Ku, Ku70 G22P1, Ku80, Ku_C, Ku_N, Ku_PK_bind, XRCC5, XRCC6
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