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Krabbe disease (also known as globoid cell leukodystrophy or galactosylceramide lipidosis) is a rare often fatal degenerative disorder that affects the myelin sheath of the nervous system. It is a form of sphingolipidosis as it involves dysfunctional metabolism of sphingolipids. This condition is inherited in an autosomal recessive pattern. The disease is named after the Danish neurologist Knud Haraldsen Krabbe (1885-1965).

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