Tags: Disease.
Kernicterus is a bilirubin-induced brain dysfunction. Bilirubin is a highly neurotoxic substance that may become elevated in the serum a condition known as hyperbilirubinemia. Hyperbilirubinemia may cause bilirubin to accumulate in the gray matter of the central nervous system potentially causing irreversible neurological damage. Depending on the level of exposure the effects range from clinically unnoticeable to severe brain damage and even death.