Tags: Drug.

JWH-424 is a drug from the naphthoylindole family which acts as a cannabinoid agonist at both the CB1 and CB2 receptors but with moderate selectivity for CB2 having a Ki of 5.44nM at CB2 vs 20.9nM at CB1. The heavier 8-iodo analogue is even more CB2 selective with its 2-methyl derivative having 40x selectivity for CB2.

JWH-424_structure.png
IUPAC name
1-pentyl-3-(8-bromo-1-naphthoyl)indole

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