Tags: Drug.
JWH-098 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound JWH-081 but has markedly different affinity for the CB1 and CB2 receptors. While JWH-081 is around 10x selective for CB1 over CB2 in JWH-098 this is reversed and it is around 4 times weaker than JWH-081 at CB1 while being six times more potent at CB2 giving it a slight selectivity for CB2 overall.
