Tags: Chemical Compound, Chemical Substance.

JTV-519 (K201) is a 14-benzothiazepine derivative that interacts with many cellular targets. It has many structural similarities to diltiazem a Ca2+ channel blocker used for treatment of hypertension angina pectoris and some types of arrhythmias. JTV-519 acts in the sarcoplasmic reticulum (SR) of cardiac myocytes by binding to and stabilizing the ryanodine receptor (RyR2) in its closed state.

JTV-519.svg
IUPAC name
3-(4-Benzyl-1-piperidinyl)-1-(7-methoxy-23-dihydro-14-benzothiazepin-4(5H)-yl)-1-propanone

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