Tags: Disease.
Genes involved in iron metabolism disorders include HFE and TFR2.Hepcidin is the master regulator of iron metabolism and therefore most genetic forms of iron overload can be thought of as relative hepcidin deficiency in one way or another. For instance a severe form of iron overload juvenile hemochromatosis is a result of severe hepcidin deficiency. The majority of cases are caused by mutations in the hemojuvelin gene (HJV or RGMc/repulsive guidance molecule c).