Tags: Chemical Compound, Chemical Substance.

Irofulven or 6-hydroxymethylacylfulvene (also known as HMAF of MGI-114) is an antitumor agent. It belongs to the family of drugs called alkylating agents. It inhibits the replication of DNA.Irofulven is an analogue of illudin S a sesquiterpene toxin found in mushrooms of the genus Omphalotus. The compound was originally synthesized by Dr. Trevor McMorris (UCSD) and found to have anticancer properties by Dr. Michael J Kelner (UCSD).

Irofulven.svg
FDA UNII code
6B799IH05A
IUPAC name
(6R)-6'-hydroxy-3'-(hydroxymethyl)-2'4'6'-trimethylspiro[cyclopropane-15'-inden]-7'(6H)-one

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