Tags: Enzyme.
IMP dehydrogenase EC 1.1.1.205 (Inosine-5′-monophosphate dehydrogenase) (Inosinic acid dehydrogenaseis) (IMPDH) an enzyme that converts inosine monophosphate to xanthosine monophosphate:inosine 5′-phosphate + NAD+ + H2O xanthosine 5′-phosphate + NADH + H+It catalyzes the rate-limiting reaction of de novo GTP biosynthesis.IMP dehydrogenase is associated with cell proliferation and is a possible target for cancer chemotherapy. Mammalian and bacterial IMPDHs are tetramers of identical chains.
