Tags: Protein.
In molecular biology the IMD domain (IRSp53 and MIM (missing in metastases) homology Domain) is a BAR-like domain of approximately 250 amino acids found at the N-terminus in the insulin receptor tyrosine kinase substrate p53 (IRSp53/BAIAP2) and in the evolutionarily related IRSp53/MIM (MTSS1) family. In IRSp53 a ubiquitous regulator of the actin cytoskeleton the IMD domain acts as conserved F-actin bundling domain involved in filopodium formation.
