Idarubicin /ˌaɪdəˈruːbɨsɪn/ or 4-demethoxydaunorubicin is an anthracycline antileukemic drug. It inserts itself into DNA and prevents DNA from unwinding by interfering with the enzyme topoisomerase II. It is an analog of daunorubicin but the absence of a methoxy group increases its fat solubility and cellular uptake.Similar to other anthracyclines it also induces histone eviction from chromatin.It belongs to the family of drugs called antitumor antibiotics.
This page contains content from the copyrighted Wikipedia article "Idarubicin"; that content is used under the GNU Free Documentation License (GFDL). You may redistribute it, verbatim or modified, providing that you comply with the terms of the GFDL.
