Tags: Protein.
Islet cell autoantigen 1 is a protein that in humans is encoded by the ICA1 gene.This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren’s syndrome.