Tags: Protein.
Estradiol 17-beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.In mice the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol testosterone and dihydrotestosterone. However the enzyme has some reductive activity and can synthesize estradiol from estrone.