Tags: Disease.

Howel–Evans syndrome is an extremely rare condition in which the skin of the palms of the hands and soles of the feet are affected (hyperkeratosis). It was described in 1958.It is also known as – Familial keratoderma with carcinoma of the esophagus Focal non-epidermolytic palmoplantar keratoderma with carcinoma of the esophagus Palmoplantar ectodermal dysplasia type III Palmoplantar keratoderma associated with esophageal cancer Tylosis and Tylosis–Esophageal cancer

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